抄録
PLGA nanoparticles (NPs) have possibility to become the useful oral DDS for nucleic acid drug. The nanocomposite powder that PLGA NPs dispersed in matrix of excipient were prepared to make two kinds of solid dosage forms such as the enteric tablet and seamless capsule containing the NF-κB decoy nucleic acid loaded PLGA NPs for human oral administration model. These two solid dosage forms proposed here showed to be high applicable for the oral DDS.
