Particle Design Using Nano-assembly Structure of Transglycosylated Materials

Abstract

The particle design with functional properties is an important aspect for the pharmaceutical and food sciences. Poor water solubility of active ingredient and/or food constituent may lead to a crucial absorption problem. To overcome this problem, we investigated the feasibility of recently developed transglycosylated additives, e.g., α-glucosyl hesperidin, α-glucosyl stevia, and α-glucosyl rutin, to improve the dissolution and bioavailability of poorly water-soluble drug and food ingredient. We found that trans-glycosylated materials formed self-associated aggregated-nanostructures in aqueous media, and their structure was different among three. The poorly water soluble drugs could intercorporate the nanostructure, creating nanocomposite structure of hydrophobic drug/transglycosylated additives. The best way to create a functional of hydrophobic compounds/transglycosylated additives was found to be a spray-drying. Spray-dried particles of drug/trans-glycosylated materials showed a significantly higher dissolution rate and greater absorption profile compared with the commercial drug powder.