Formulation Design Based on the Physicochemical Characterization of Cyclodextrin-Drug Interaction

Abstract

Salt forms are frequently used in solid dosage forms because they can improve aqueous solubility and chemical stability relative to the non-ionic form of the active compound. However, absorption of drugs through biological membranes could be improved by enhancing the solubility of the non-ionic form by using cyclodextrins （CDs） because the non-ionic form is more hydrophobic than the ionic form （salts）. In this paper, the studies about improvement of water solubility and physicochemical characterization of CD-drug interaction in the solid and solution state were introduced using fentanyl base as a model of poorly water soluble drugs （free base） and CDs.