解説
機能性高分子の表面修飾による細胞特異的リポソームDDSの設計
2018 年 55 巻 7 号 p. 389-396
詳細
2018 年 55 巻 7 号 p. 389-396
Surface modification of functional polymers onto liposomes is effective strategy to obtain functional liposomes that release drugs at target site or intracellular compartments. Here, design of pH-sensitive liposomes for cell-specific intracellular drug delivery was summarized. Liposomes modified with hyaluronic acid derivatives exhibited selective anticancer drug delivery to CD44-expressing cancer cells. Furthermore, liposomes modified with curdlan derivatives were efficiently recognized by dendritic cells, leading to efficient antigen delivery, activation of dendritic cell and induction of antitumor immunity on tumor-bearing mice. Therefore, functional polymer-modified liposomes are promising for cell-selective cancer chemotherapeutic system or immunotherapeutic systems.
