2023 年 60 巻 11 号 p. 689-697
Dry particulate coating process has been proposed as a cost-effective unit operation for preparing particles with controlled drug release. In this process, nanoscale solid-state coating particles are mechanically coated onto the surface of the drug-containing core particles (c.a. 100 μm). Although this process has been reported in many previous studies, several outstanding issues need addressing before it can replace the current standard method: the wet particulate coating technique employing a fluidized bed. In the realm of material design, traditional coating agents for the wet process have not considered solid-state adhesion. Moreover, the operational and material factors influencing coverage remain undefined. This review summarizes previously studied materials and apparatus, and details our research into the development of acrylic coating agents and the understanding of the coating mechanism.
