脂質メディアを利用した医薬品成分の共結晶形成

抄録

Pharmaceutical cocrystal is expected to improve its bioavailability in human body. There are several drawbacks of using a large amount of organic solvent and heating operation for removing the solvent on conventional cocrystal formation techniques. This work provides a new type of pharmaceutical cocrystal formation in lipid media. Theophylline, caffeine, ibuprofen and itraconazole were used as active pharmaceutical ingredients for the cocrystal formation in lipid media using oleic acid or linoleic acid. The lipid media achieves the promotion of the cocrystal formation for theophylline, caffeine and ibuprofen at the room temperature. The cocrystal of itraconazole can be formed in lipid media at the higher temperature.