Usefulness of Time-Domain NMR in Characterizing Pharmaceutical Properties

Abstract

The purpose of this study is to demonstrate the usefulness of time-domain NMR (TD-NMR) in characterizing the physicochemical properties of pharmaceuticals, particularly solid dosage forms. TD-NMR is a technique specialized in the measurement of ¹H-NMR relaxometry that enables rapid and easy measurement of NMR parameters, including T₁ and T₂ relaxation times. These parameters are closely linked to the molecular mobility of substances; thus, allowing us to investigate the physicochemical properties of samples based on this aspect. With the expectation that TD-NMR would prove to be a powerful tool in pharmaceutical evaluations, our research group has been gathering evidence across various research projects. This article presented two case studies using TD-NMR: one that investigated the crystalline state of active pharmaceutical ingredients (APIs) and another that examined the effect of molecular mobility of hygroscopic water in excipients on the hydrolysis of APIs.