Abstract
It was found that the tablet hardness linearly increased with increasing milling time without further decreasing the particle size of powder.
The above finding might be due to the fact that the tablet hardness was independent of the average particle size of the compressed powder, but it depended on the degree of destruction of the crystal lattice.
This was confirmed by the significant correlations between the tablet hardness and the relative intensity in the X-ray diffraction pattern and the maximum endothermic peak in differential thermogram.
