噴霧乾燥HPC-Lを結合剤として用いた低成形性医薬品粉末の直接打錠
2006 年 43 巻 9 号 p. 648-652
詳細
2006 年 43 巻 9 号 p. 648-652
The binding effect of hydroxypropylcellulose (HPC-L) in direct compaction of pharmaceutical powders was evaluated. Several types of HPC-L particles having different properties were tested in direct compaction of poorly compactable powders, erythritol and ascorbic acid.When the particle size of HPC-L in the tablet formulation was decreased, the hardness of resultant tablet increased. In comparing the spray-dried HPC-L and the freeze-ground one, the spray-dried HPC-L showed higher tablet hardness although their particle sizes were comparable. The different binding effects of these powders were attributed to the more spherical shape and smoother surface of spray-dried particle. The hardness of tablet containing 2% of the fine spray-dried particles was significantly higher than that containing 10% of commercial HPC-L. Thus, the fine HPC-L particles prepared with spray-drying is one of the most suitable binders in direct compression.
