Nutrition Index is Maintained for Five Years after Pylorus-Preserving Pancreatoduodenectomy

抄録

[Background/Objective] We assessed trends in serum nutritional status markers and body mass index (BMI) to evaluate the long-term nutritional status in patients with pylorus-preserving pancreatoduodenectomy (PPPD).
[Methods] From 240 patients who underwent PD from January 2005 to October 2014, we selected 45 patients who underwent PPPD and had survived without recurrence at 5-year postoperative follow-up. The following factors were analyzed preoperatively and at 2 weeks, and 1, 5 years, postoperatively: serum total protein (TP), serum albumin (Alb), and body mass index (BMI).
[Results] The mean TP value was 6.8 g/dL preoperatively and 6.3 and 7.1 g/dL at 2 weeks and 1 year after surgery, respectively (P<0.0001, P=0.026, respectively). TP remained greater than the preoperative values for up to 5 years. The mean Alb value was 4.1 g/dL preoperatively, decreased to 3.5 g/dL 2 weeks after surgery, but returned to 4.15 g/dL 1 year after surgery and to 4.13 g/dL 5 years after surgery, values approximately equivalent to the preoperative value (P=0.134, P=0.505, respectively). The mean preoperative BMI was 22.1 kg/m², decreased to 17.3 kg/m² 2 weeks after surgery (P<0.001), and then rose to 19.0 kg/m² by 5 years after surgery (P=0.005), but remained within the standard range in 29 patients (64.4%).
[Conclusion] Long-term nutritional status was adequately maintained postoperatively in patients who underwent PPPD.