Journal of St. Marianna University
Online ISSN : 2189-0277
Print ISSN : 2185-1336
ISSN-L : 2185-1336
原著
Antimicrobial and Antibiofilm Effects of Ozonated Water for Prevention and Treatment of Bone and Joint Infections
Ryouta KoyamaKen-ichi OkudaKazuhiko MatsushitaMoroe BeppuYoshimitsu Mizunoe
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ジャーナル フリー

2015 年 6 巻 1 号 p. 1-7

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抄録
Antimicrobial effects of ozonated water for the planktonic cells and the biofilm cells of staphylococci were examined for clinical applications in the orthopaedic field. As a result, 7 mg/L of ozonated water showed antimicrobial effects for not only the planktonic cells but also for the biofilm cells. Additionally, antimicrobial activity of ozonated water was examined after destroying the biofilm using 1 M NaCl or proteolytic enzymes (proteinase K and trypsin). Interaction between ozonated water and biofilm destruction was statistically significant in 2 strains (SE21, MR23) out of 8 strains. However, the effects of proteinase K or trypsin with ozonated water were statistically significant only in MRSA MR23. MRSA MR23 was previously reported to be a proteinaceous biofilm producer, and its biofilm was destructed by various proteases.
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© 2015 St. Marianna University Society of Medical Science
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