抄録
The squamous odontogenic tumor (SOT) represents one of the extremely rare odontogenic epithelial neoplasms originating probably from the rests of Malassez in the periodontal ligament. The common site of this tumor is the alveolar process in close proximity to the roots of permanent teeth. We reported a case of relatively large SOT involving the body of the mandible in a 54-year-old female. Radiographically, a well-defined multilocular lesion was revealed in the median alveolar to the mandible. Through a histological examination of a biopsy specimen, it was seen that the lesion consisted of varied sizes of islands of well-differentiated squamous epithelium embedded in a fibrous connective stroma and was diagnosed as SOT. As a result of immunohistochemical analysis of cytokeratins (CKs), the tumor cells were mostly stained by AE1/AE3 (pan-keratin), although they were negative for CAM5.2 (CK8) and CK19. This expression pattern of CKs suggested that the tumor cells differentiated into squamous epithelium. The tumor was intraorally extirpated under general anesthesia. There was no recurrence after seven years of follow up.
