担癌ハムスターの高脂血症

抄録

Cancer cachexia is frequently accompanied by hyperlipidemia. To identify the mechanism underlying these changes in lipid metabolism, serum triglyceride (TG) alterations in hamster cheek pouch carcinogenesis were determined. TG concentration in tumor-bearing hamsters showed a significant increase from an early stage in comparison with other lipids, while the activity of lipoprotein lipase (LPL), the key enzyme of TG metabolism, was drastically reduced. As for the origin of tumor necrosis factor-α(TNF-α), TNF-α was found to be present in both the sera and the extract of tumor from tumor-bearing banisters. Depending upon the concentration of TNF-α added to preincubation, the result was a significant inhibition of LPL activity. Therefore, TNF-α increase in vivo caused the increase of TG in DMBA induced carcinoma bearing hamsters. In this investigation, a study on other serum lipid alterations in hamster cheek pouch carcinogenesis was also conducted.