The purpose of this study was to examine whether perceived stress and Sense of Coherence (SOC) were associated with Mibyou (presymptomatic disease) from Oriental medicine among community-dwelling Japanese. Participants were 651 men and 1,183women aged 30 to 79 years who participated in the Toon Health Study, which was conducted in Toon city, Ehime prefecture, from 2011 to 2015. Mibyou was assessed using the Oriental Medicine Health Questionnaire 57 (OHQ57); a total score of ≥ 29 points on the OHQ57 indicated presence of Mibyou. Perceived stress was assessed using a self-administered questionnaire. SOC was assessed using a 13-item Japanese version of the SOC scale. Gender and age group-specific analyses were performed using logistic regression model. The prevalence of Mibyou was positively associated with the perceived stress (p < .01), and negatively associated with SOC (trend p < .01) among men and women. Age-adjusted odds ratio (95% confidence intervals) of Mibyou for participants with perceived stress and low-median score of SOC was 8.35 (5.20-13.41) for men and 9.25 (6.39-13.41) for women, compared with those without perceived stress and with high SOC. Our findings suggested that the measure for Mibyou was important especially for people with perceived stress and low SOC.