Efficacy of perioperative oral cefcapene pivoxil for surgical site infection prophylaxis in patients with urological diseases

抄録

This single-center, retrospective study was aimed to evaluate the prophylactic efficacy of oral cefcapene pivoxil （CFPN-PI） in preventing perioperative surgical site infections （SSIs）. We obtained hospital records of patients on CFPN-PI prescription between August 25, 2014, and August 25, 2017, at Showa University Hospital in Tokyo, Japan. Patients hospitalized for urological surgery were divided into the CFPN-PI group and non-CFPN-PI group according to administration of antibiotic injection within 72hr of surgery. The incidence of SSI was calculated up to 30 days postoperation in both groups. Of the 1,158 patients, 360 met the inclusion criteria, and 207 received oral cephalosporin and 153 did not. The incidence of SSI was 4.8％ and 3.2％ in the CFPN-PI and the non-CFPN-PI groups, respectively. The incidence of SSI was not significantly different between the two groups （crude odds ratio: 1.5, 95％ confidence interval: 0.50-4.50, p＝0.59）. Perioperative, prophylactic, oral administration of CFPN-PI does not reduce the risk of SSI in patients who have undergone urological surgery.