抄録
We examined the effects of maternal glycosuria during pregnancy on obesity in female offspring of reproductive age （Offspring-Re）. Data from Maternal and Child Health Handbooks maintained by the mothers of Offspring-Re at the time of their births were used in this single-center study. Offspring-Re with records of maternal glycosuria during pregnancy and pre-pregnancy body mass index （BMI） were recruited. Positive maternal glycosuria during pregnancy was defined as having at least one recorded （＋） or higher in the handbook. Obesity in Offspring-Re was defined as a pre-pregnancy BMI of ≥25kg/m2. To estimate the effect of maternal glycosuria on obesity in Offspring-Re, logistic regression analysis was performed. Of the 313 Offspring-Re included, maternal glycosuria was positive and negative in 45 and 268, respectively. The incidence of obesity in Offspring-Re was 13.3％ and 2.6％ in the positive and negative maternal glycosuria groups, respectively （p＝0.005）, and increased with the degree of maternal glycosuria （p＝0.0001）. Multiple logistic regression analysis revealed that positive maternal glycosuria during pregnancy was a significant risk factor for obesity in Offspring-Re, even after adjusting for maternal pre-pregnancy BMI, gestational weight gain, and maternal high blood pressure during pregnancy （adjusted odds ratio, 5.50; 95％ confidence interval, 1.55-19.15; p＝0.010）. Collectively, these findings indicate that maternal glycosuria during pregnancy is a risk factor for obesity in Offspring-Re.
