抄録
Microsatellite markers are useful markers for genetic linkage analysis. However, it has been demonstrated that ethnicity plays a significant role in genetic variation. To investigate genetic variation between the Korean and Japanese populations, 51 microsatellite marker loci spanning the entire human chromosome 1 were acquired from a commercially available set (ABI PRISM Linkage Mapping Set-HD5) . The allelic frequencies and heterozygosities for these marker loci in 96 unrelated Korean subjects and 96 unrelated Japanese subjects were determined. Of the 51 markers tested, significant differences were observed when the microsatellite allele frequency pattern of Koreans was compared with those of the Caucasian model, whereas the pattern was highly similar between the Korean and Japanese populations. Our data indicate that an extensive verification of public microsatellite markers in a particular population, especially in Koreans, should be undertaken prior to linkage studies. Moreover, our findings should facilitate genetic linkage studies of various hereditary diseases.
