抄録
Steroid sulfatase (STS) in breast carcinoma is an important enzyme in intratumoral estrogen synthesis. Twenty-two paraffin-embedded surgical specimens from non-invasive ductal carcinoma (DCIS) of the breast and 32 specimens from invasive ductal carcinoma (IDC) were stained using the STS and estrogen receptor (ER) polychronal antibodies. Immunoreactivity for STS in ER positive tumor was 82 % (14/17) in DCIS, 75 % (12/16) in T1 and 56% (5/9) in T2 without lymph node involvement. The incidence of immunoreactivity for STS of DCIS tended to be higher than that of IDC, although it did not reach statistical difference. These results suggest that STS in breast carcinoma may be involved in the process of carcinogenesis of the breast.
