Abstract
One of the most powerful means for the identification of protein networks is LC (liquid chromatography) based electrospray LC-MS/MS (tandem mass spectrometry).
Even with such high-tech devices, large-scale protein interaction analysis is still a challenge. To enhance the sensitivity and resolution of LC-MS/MS analysis, we have developed a novel LC-MSMS system with direct nano-scale flow control. Using this system, we discovered new interactions of disease-related or causative proteins, uncovering precise molecular mechanisms of several diseases for drug discovery.
