Abstract
We have performed a clinicopathological study of the modes of spread of gallbladder carcinoma in 123 resected specimens. The frequency of major modes of spread were as follows, invasion to the liver 43%, invasion to the hepatoduodenal ligament 39%, invasion to other organs 29% and lymph node metastases 68%, respectively. When we analyzed the mode of invasion to the liver, we found out that when the site of invasion was at the liver bed, intrahepatic spread was relatively localized and expansive growth, whereas when the invasion was at the hepatic hilum, most of cases showed infiltrative spread deep in to the liver. Most of the invasion to the hepatoduodenal ligament were marked and there were high frequency of lymphatic, venous and perineural invasion with 70~97%. Main sites of lymph node metastases were,12 b 2,13 a,8 and 14 respectively. There was a correlation between the site of tumor and frequency of lymph node metastases among the cases in which the depth of infiltration was to the subserosa.
