抄録
This review indicates a possible biological concept for an application of carbon-based materials based on a recent established physiological knowledge. A key point of this review is to open a new avenue to povide a new material into our life by integtating a poject-oriented task work together with several different kinds of scientific fields. In order to disclose the above concept, severalexperimental evidences have been demonstrated. Firstly, immunological reactions of activated carbon fibers (ACFs) have been detected by measuring CD4 and CD8 cells in mice that have been implanted ACFs subcutaneously for 6 months. Histological examinations have been done. An important parameter of surface area and/or pore-size has been demonstrated. Second, ability of IgE-induced histamine release from rat mast cells was also investigated in vitro to confirm whether ACFs has a potency of inducers of acute allergic reactions. Thirdly, fundtions of cells growing and/proliferation were influenced under coexisting enviroment with ACFs in vitro. It was found by using newly planned and sythesized materials (our ID: HDI) that an optimal survival parameter of a cell survival was dependent on the pore-size of materials. In addiction, bioimplantable materials have been reviewed and application fields of carbon-based materials have been discussed. As an overall, this review has shown that scientific field of this carbonalloy (carbon-based materials) has a great potency to lead into a new scientific frontier toward many biomedical applications.
