抄録
The structure and absolute configuration of kidamycin C_<39>H_<48>N_2O_9. 1/2 H_2O, an antitumor antibiotic produced by a Streptomyces species, have been elucidated as shown in Fig 4 (1-a) on the basis of spectroscopic, chemical and X-ray crystallographic studies. Methylation of kidamycin triacetate with CH_3I, followed by methanolysis gave triacetylmethoxy kidamycin bis(methyl-ammonium iodide) whose structure was determined as shown in Fig 1 by an X-ray analysis, Kidamycin is convertible by acid into isokidamycin (Fig 5 (2-a)) whose structure was also clarified by an X-ray analysis of its halogeno derivatives. From these results structure of kidamycin was deduced. Kidamycin represents a new class of polycyclic microbial metabolites, possessing a skeleton composed of a pyrone ring-fused anthraquinone as a chromophore and two C-glycosidic amino sugar rings. As for the conformation of amino sugar ring, one is chair and the other is boat. The latter, on isomerization, is rearranged to chair.
