Inhibitory Effect of Persimmon Peel Extract on Insulin Resistance in High-fat diet-fed Mice

Abstract

Large amounts of unused rind are discarded during dried persimmon production. Comprehensive gene expression analysis has shown that the consumption of fat-soluble persimmon peel extract (PPE) improves insulin resistance in animal models of diabetes. However, no changes in blood glucose levels and other parameters have been reported to date. Therefore, the purpose of this study is to investigate the effect of PPE on the insulin resistance of male mice fed a highfat diet (60% fat) with 1.5% PPE for six weeks via glucose tolerance test. High-fat diet with PPE decreased the blood glucose levels after glucose loading better than the high-fat diet alone. However, no significant decrease in adipose tissue weight was observed, indicating that PPE alleviated high-fat dietinduced insulin resistance.