Recent Synthetic Approaches to Inner-core Oligosaccharides of Lipopolysaccharides and Lipooligosaccharides

Abstract

Lipopolysaccharides (LPSs) and lipooligosaccharides (LOSs) are target molecules for the development of vaccines against pathogenic Gram-negative bacterial infections. The chemical synthesis of the core oligosaccharides of LPSs/LOSs remains a major challenge. Herein, recent reports of the chemical synthesis of inner-core oligosaccharides containing 3-deoxy-D-manno-oct-2-ulosonic acid are reviewed.