Trends in Glycoscience and Glycotechnology
Online ISSN : 1883-2113
Print ISSN : 0915-7352
ISSN-L : 0915-7352
Article for JSCR 40th Anniversary Issue
Function and Structure Analysis of Glycolipid Microdomains
Kazuya Kabayama
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2019 Volume 31 Issue 181 Pages SE78-SE79

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Abstract

Glycosphingolipids are not uniformly present in cell membranes and form microdomains called glycolipid microdomains together with sphingomyelin and cholesterol. Many signaling molecules accumulate there, and glycolipid composition greatly influences signal transmission efficiency. Therefore, analyzing the dynamics and structure of glycolipid microdomains is very important in understanding life phenomena. In recent glycolipid microdomain studies, along with biochemical methods, analysis of membrane molecular dynamics by fluorescence microscopy, localization analysis using an electron microscope, and lipid structure analysis by mass spectrometry have been conducted. Here I outlined a super-resolution microscope that can be widely used for glycolipid microdomain analysis.

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© 2019 FCCA (Forum: Carbohydrates Coming of Age)
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