Trends in Glycoscience and Glycotechnology
Online ISSN : 1883-2113
Print ISSN : 0915-7352
ISSN-L : 0915-7352
Chemical Biology Study on N-glycans
Yoshiyuki Manabe
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2021 Volume 33 Issue 193 Pages E63-E67


N-Glycans, which are post-translational glycosylation modifications on asparagine, have diverse structures, and their functions vary based on their structures. Recent advances in the chemical, enzymatic, and chemoenzymatic synthesis and isolation of N-glycans have made it possible to produce high quantities of various N-glycans. These N-glycans have been widely used in chemical biology studies on elucidating their functions. Interaction analyses between lectins and various N-glycans have revealed the molecular basis of the recognition of N-glycans. In addition, proteins modified with chemically synthesized homogeneous N-glycans revealed the effects of N-glycan modification on protein function. Furthermore, the applications of N-glycans in drug development have been explored. This review introduces the recent advances in the chemical biology study on N-glycans.

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