Trends in Glycoscience and Glycotechnology
Online ISSN : 1883-2113
Print ISSN : 0915-7352
ISSN-L : 0915-7352
GLYCOREVIEW (Jpn. Ed.)
Substrate Specificity of Chondroitinase ABC-I Based on Analyses of Biochemical Reactions and Crystal Structure
Ippei WatanabeAkimasa Miyanaga
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2023 Volume 35 Issue 208 Pages J95-J100

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Abstract

Chondroitinase ABC-I (cABC-I) has been studied for many years as an enzyme that degrades chondroitin sulfate (CS). There are several isomers of CS, and the reactivity with cABC-I is also different for each CS isomer. In this paper, we review the substrate specificity of cABC-I based on the results of analyzing cABC-I reactivity to CS that is more homogeneous, and the crystal structure of the cABC-I complex with unsaturated disaccharide derived from CS.

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© 2023 FCCA (Forum: Carbohydrates Coming of Age)
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