Abstract
Sialyltransferase is one of the most demanding glycosyltransferases since chemical sialylation is usually furnished in low yield with low stereoselectivity. Recently, several bacterial sialyltransferases were shown to exhibit broader substrate specificity than that of mammalian counterparts. This suggests the potential usefulness of bacterial sialyltransferases in chemoenzymatic synthesis of natural and nonnatural sialooligosaccharides and sialoglycoconjugates.
