The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Regular Contributions
Effect of Interferon-γ on Lymphocyte Cell Subsets in Human Large Bowel: A Study Using Organ Culture Method
Toshio Suzuki, Yasuo Horie, Mitsuro Chiba, Masahiro Iizuka, Osamu Masamune
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キーワード: IFN-γ, large intestine, lymphocyte subsets, organ culture
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1997 年 181 巻 4 号 p. 431-446

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This study was conducted to investigate the effects of interferon (IFN)-γ on normal colonic lamina propria lymphocyte subsets in humans using organ culture method. Lamina propria lymphocyte subsets in normal colonic biopsy tissues receiving 1×105 u/ml of IFN-γ (IFN-γ-treated group) were investigated in comparison with those cultured in medium only (IFN-γ-non-treated group) for 24 hr. CD8-positive cells and IgG, IgAl and 1gM-containing cells were elevated in the IFN-γ-treated group compared with those in the IFN-γ-non-treated group, which was similar to immunological changes in mucosal lesions of inflammatory bowel disease.
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© 1997 Tohoku University Medical Press
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  • About this Journal
    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.


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