The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Regular Contributions
Strychnine-Sensitive and Strychnine-Insensitive Glycine Binding Sites in the Spinal Cord of the Wobbler Mouse
Masahiko TomiyamaKazuya KannariMuneo Matsunaga
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1997 年 183 巻 1 号 p. 37-43

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Using quantitative autoradiography, the strychnine-sensitive glycine site and strychnine-insensitive glycine site of the N-methyl-D-aspartate receptor were analyzed in the cervical segment of the spinal cord of the wobbler mouse, which is a purported model of human motor neuron diseases. Significantly increased density of the strychnine-sensitive site was found in the lamina II-inner (+17%) and laminae III & IV (+17%) of wobbler mice. The strychnine-insensitive site was also increased in lamina I & II-outer (+ 15%), lamina II-inner (+15%), laminae III & IV (+48%), laminae V-VIII (+ 43%) and lamina X (+ 26%) of wobbler mice. However, no significant differences were observed for the both sites in the ventral horn where motor neurons are located. These findings suggest that both inhibitory and excitatory-associated glycinergic dysfunctions are involved in the wobbler mouse motor neuron disease.
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© 1997 Tohoku University Medical Press
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