Abstract
We found a glycoside in sera of schizophrenic patients. This glycoside increased climbing of mouse forced swimming and the climbing was decreased by dopamine D1 receptor antagonist SCH-23390 with a dose dependent manner. This glycoside had much reactivity of GalNAcα1-3GalNAc, but not that of polymannoses nor that of Galβ1-3GlcNAcα1-serine or threonine. This strongly suggests that the glycoside is an isolated O-glycoside, but not -glycoside nor O-glycoside having core 1 or 2. The present findings suggest that schizophrenic patients have the special glycoside affecting the D1 receptor activity in their serum.
