The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
Review
Molecular Biology of Blood Pressure Regulatory Genes
KAZUHISA TAKEUCHI
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2002 Volume 197 Issue 1 Pages 1-8

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Abstract

Blood pressure is determined by vascular resistance and circulating volume. Activation of vascular angiotensin II or thromboxane receptor is mostly involved in the former, and function of renal prostaglandin EP3 receptor or thiazide-sensitive sodium-chloride co-transporter is also in the latter. We have cloned rat genes for these blood pressure regulatory factors, and studied their gene expression. Here we review the molecular biology of those genes, based on our observations.

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© 2002 Tohoku University Medical Press
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