The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Regular Contributions
Effect of Recombinant Basic Fibroblast Growth Factor (bFGF) on Fibroblast-Like Cells from Human Rotator Cuff Tendon
SHU TAKAHASHI, MIZUHO NAKAJIMA, MOTO KOBAYASHI, IKUKO WAKABAYASHI, NAOHISA MIYAKOSHI, HIROSHl MINAGAWA, EIJI ITOI
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Keywords: basic fibroblast growth factor, rotator cuff tendon, collagen, proliferation, primary culture
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2002 Volume 198 Issue 4 Pages 207-214

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Abstract
Rotator cuff tendon cells (RCC) derived from surgical samples showed fibroblast-like morphology. Histological staining demonstrated collagen secretion by RCC. Immunohistological findings revealed that RCC secreted type I and III collagen, but not type II collagen. In addition, the SDS-PAGE analysis suggested that RCC predominantly produced type I collagen. Basic fibroblast growth factor (bFGF) had a stimulatory effect on the proliferation of RCC dose-dependently up to 1 ng/ml. Administration of bFGF suppressed the secretion of collagens from RCC in a dose-dependent manner.
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© 2002 Tohoku University Medical Press
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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.

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