The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
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Nitric Oxide Synthase Inhibition by L-NAME in Streptozotocin Induced Diabetic Rats: Impacts on Oxidative Stress
Arzu Seven, Savas Güzel, Oktay Seymen, Sabiha Civelek, Murat Bolayirli, Günnur Yigit, Gülden Burçak
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キーワード: nitric oxide, L-NAME, diabetes, oxidative stress
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2003 年 199 巻 4 号 p. 205-210

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The effects of nitric oxide synthase (NOS) inhibition by Nw-nitro-L-arginine methyl ester (L-NAME) administration on oxidative stress parameters were investigated in streptozotocin (STZ) induced diabetic rats. Lipid peroxidation as reflected by thiobarbituric acid reactive substances (TBARS) was insignificantly higher in diabetic rats. Plasma NO2+NO3 values (p<0.05) and erythrocyte CuZn superoxide dismutase (CuZn SOD) and glutathione peroxidase (GSH Px) activities were significantly higher (p<0.01, p<0.001, respectively) in diabetic rats. L-NAME administration to diabetic rats caused significantly lower CuZn SOD and GSH Px activities (p<0.01) and NO2+NO3 values (p<0.001), whereas a significantly higher GSH level (p<0.01). TBARS-/GSH ratio was significantly higher in diabetic rats than controls (p<0.05) and significantly lower in L-NAME administered diabetic rats than diabetic rats (p<0.05). This experimental study highlightens the importance of NOS inhibition by L-NAME in the attenuation of oxidative stress in STZ diabetic rats.
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© 2003 Tohoku University Medical Press
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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.


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