Antiviral Activity of 2-Amino-4, 4α-Dihydro-4α-7-Dimethyl-3H-Phenoxazine-3-One on Poliovirus

Abstract

2-Amino-4, 4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-one (Phx), which was produced by the reaction of bovine hemoglobin with 2-amino-5-methylphenol, inhibited the proliferation of poliovirus in Vero cells between 0.25 μg-/ml and 2 μg-/ml with maximal antiviral acitivity at 1 μg-/ml. These results suggest that Phx may be useful to prevent the proliferation of poliovirus infection.