Elevated Plasma Homocysteine Concentrations in Severe Preeclampsia and Eclampsia

Abstract

Homocysteine is an essential amino acid required for the growth of cells and tissues in the human body. Maternal hyperhomocysteinemia is associated with a number of placenta-mediated diseases such as preeclampsia. The aim of this study was to evaluate the plasma level of homocysteine and its association with severity of preeclampsia. A case-control study was performed with 32 mild preeclamptic patients, 25 severe preeclamptic patients, 16 eclamptic patients and 34 controls. Maternal plasma homocysteine concentration was measured prospectively at antenatal period by high-performance liquid chromatography. There were no significant differences in demographic characteristics between the study and control groups. Mean plasma levels of homocysteine in women with severe preeclampsia (16.7 ± 10.1 μmol/l, mean ± S.D., n = 25) and eclampsia (16.5 ± 9.6 μmol/l, mean ± S.D., n = 16) were significantly higher than those in mild preeclampsia (7.7 ± 2.4 μmol/l, mean ± S.D., n = 32) and controls (6.7 ± 1.6 μmol/l, mean ± S.D., n = 34) (p < 0.0001). It should be noted that plasma levels of homocysteine are not significantly different between mild preeclampsia and controls. In conclusion, plasma homocysteine concentrations are increased in severe preeclampsia and eclampsia, but not in mild preeclampsia.