The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
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Behçet’s Disease with Extremely High Levels of Urinary β2-Microglobulin after Non-Steroidal Anti-Inflammatory Drug Treatment
Ryohei Ogino, Karin Shimada, Daiki Narai, Masanori Goto, Katsuhiro Sato, Yoshihisa Katsuta, Akimasa Shiigi, Juri Ueda, Chika Oyama, Yuko Fujikawa, Isabelle Miyazawa, Takahiro Ohara, Kazuhiro Sumitomo, Shigeru Sato, Nobuo Koinuma, Atsuhiro Kanno, Katsutoshi Furukawa
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Keywords: Behçet’s disease, β2-microglobulin, creatinine, non-steroidal anti-inflammatory drug, renal dysfunction
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2021 Volume 254 Issue 4 Pages 283-286

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Abstract

Behçet’s disease is an inflammatory disease which manifests itself as various symptoms, such as uveitis, oral and genital aphthae, erythema nodosa, gastro-intestinal ulcerations and encephalopathy. Among the manifestations, renal dysfunction is reported in some percentage of the patients with this disorder. We experienced a middle-aged male with Behçet’s disease who showed an extremely high level of urinary β2-microglulin, which is one of the markers of renal dysfunction, despite normal serum creatinine levels. The patient was on non-steroidal anti-inflammatory drug (NSAID) therapy for 7 weeks, and this could have affected his renal dysfunction. The present report suggests that renal injury should not be underestimated in patients with Behçet’s disease, especially in patients using NSAIDs.

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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.

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