The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Serm Sulfhydryl Levels and Rheumatoid Factors in Rheumatoid Arthritis
Shiro Kosaka
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1970 Volume 100 Issue 4 Pages 349-358

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Abstract
Serum total sulfhydryl level (SH-level) was determined in 285 cases of rheumatoid arthritis and other allied diseases and of healthy subjects. The SH-level was within the normal limits in 28 of 33 cases of rheumatoid arthritis. However, it was slightly lower than that of the controls. The SH-level was subnormal in the remaining 5 cases. These 5 cases showed high titer of rheumatoid factors and an increase in the amount of IgM. The results suggest that the formation of macroglobulin, particularly that of rheumatoid factor is related to a decrease of SH-level. When L-cysteine was injected into the joint cavity of a patient, IgM disappeared temporarily from the synovial fluid at 30min and 3hr. Glutathione had not such an effect. Thus, different SH-compounds seem to exert different effects on the organism.
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