The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Experimental Study of the Isolated Canine Kidney Perfusion with Special Reference to Effects of Various Vasodilator Agents
CHEN TIE HWANG, EIAKI TSUTSUMI, HIROSHI SUZUKI, KAZUHIKO TAKANO, NAOYA MATOBA
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キーワード: kidney perfusion, vasodilator
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1970 年 101 巻 2 号 p. 161-173

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Perfusions of 34 isolated canine kidneys were performed at 38°C using heparinized diluted homologous blood, and the effects of vasodilators on renal circulation and urinary output were studied. Renal pressure, renal blood flow, renal vascular resistance, urine volume, glomerular filtration rate by creatinine clearance method, and intrarenal distribution of blood flow by 131I-tagged serum albumin method were measured before and after the administration of drugs, and the following results were obtained. Papaverine and mannitol were effective in improving the circulation through the isolated kidney when proper doses were given. ATP showed biphasic effects depending on its concentration. Phenoxybenzamine isoproterenol and bradykinin showed no significant vasodilating effect on the isolated kidney perfusion.
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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.


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