Influence of Thyroid Function on Experimental Liver Injuries

Abstract

Experiments were performed with female rats to observe the correlations between thyroid function and liver damages. A method was elaborated based on the test of the total dye eliminating capacity of the rat liver. There were no essential changes in the elimination of BSP in animals with healthy liver in either hyperthyrosis or hypothyrosis. Subacute carbontetrachloride intoxication produced a slight change while chronic intoxication resulted in a severe change in the liver functions at carbontetrachloride dosages which in themselves hardly had any toxic effect. This was proven both by increased blood BSP levels and by histological findings. The total dye eliminating capacity of the liver was not impaired when carbontetrachloride treatment was performed in thyroidectomized rats. Hypothyroidism was found to have protective effect on the experimental liver lesion.