Prolongation of Canine Renal Allograft Survival in Combined Therapy with Rabbit-anti-dog Antilymphocytic Serum, Azathioprine and the Allotransplantation of the Donor's Bone Marrow
1970 年 101 巻 4 号 p. 333-338
詳細
1970 年 101 巻 4 号 p. 333-338
Seventy-four dogs received renal allografts after simultaneous bilateral nephrectomy. Five recipients were untreated, another five were given daily subcutaneous injections of normal rabbit serum, twenty-five received daily injections of rabbit-anti-dog antilymphocytic serum (ALS) at varying intervals before and after transplantation, ten were treated daily by mouth with azathioprine, fourteen received daily injections of ALS combined with azathioprine, and fifteen were treated with daily injections of ALS combined with both azathioprine and the allotransplantation of the donor's bone marrow. The mean survival time of the untreated control animals and that receiving normal rabbit serum were 9.0±1.0 and 10.0±0.3 days, respectively. No animals in these groups survived more than eleven days. In the ALS-treated dogs, some prolongation of survival was achieved when the serum was administered subcutaneously twice a day in a total dose of 1.0 ml per kg per day from 4 days before renal transplantation to 14 days after the transplantation and then once a week, and the survival time averaged 20.9±2.7 days. On the other hand, azathioprine combined with ALS and allotransplantation of the donor's bone marrow produced a mean survival of 38.4±4.7 days, a significant prolongation of functional survival over those of the other series. Accordingly, a considerable synergism was found in the combined therapy with ALS, a small dose of azathioprine and allotransplantation of the donor's bone marrow.
