Action of Animal Albumin Preparations on the Growth of Lung Cells of Newborn Hamster
1970 年 101 巻 4 号 p. 379-385
詳細
1970 年 101 巻 4 号 p. 379-385
The prominent growth-promoting effect of serum albumin fraction V was hardly observable when purified crystalline serum albumin was employed, suggesting that the chemical factor respons;ble for the activity may belong to small molecular substances bound to albumin preparation as impurity. Minute amounts of linoleic acid did not show any growth-enhancing effect and the defatted preparation exhibited the activity just like the original albumin preparation did. Fetuin exhibited a growth-promoting effect for ‘A’ cells at the 28th transfer. Egg albumin showed growth-enhancing effect for the same cells under the same condition but the activity could not be observed when albumin was replaced with crystalline one. The active component (s) was proved to be heat-stable and dialysable.
