Abstract
Three cases of atypical pneumonia with pleural effusion were reported. Two cases were siblings. There was no evidence for tuberculosis or bacterial infection in these cases. There was a significant rise of complement-fixing (CF) antibody titer to Mycoplasma pneumoniae (M. pneumoniae) in the three cases. M. pneumoniae was isolated from the pleural fluid of a case. CF antibody was demonstrated in the pleural fluid in two cases. Skin rashes were found in two cases during course of illness.