Abstract
Pharmacological features of the gall bladder and its vascular bed were studied by means of the intra-arterial administration of various substances in the dog in situ. The contraction of the gall bladder was produced by various compounds as follows: Cholinergic drugs, kinin substances, histamine, ganglion stimulants, ouabain, BaCl2 and CaCl2. Meanwhile, adrenergic drugs, ganglion blocking agents, lys-vasopressin, smooth muscle relaxants, KCl and MgCl2 relaxed the gall bladder. DMPP, 5-HT, nicotine, lobeline, angiotensin and ATP caused a biphasic response, i.e., a contraction followed by a relaxation or a relaxation followed by a contraction. The pharmacological features of cholecystic arteries are not the same as those of the gall bladder: Cholinergic and adrenergic drugs except isoprenaline, and ganglion stimulating and blocking agents produced opposite effects, while smooth muscle stimulants and relaxants acted similarly on both. Among polypeptides, lys-vasopressin relaxed the gall bladder, cholecystokinin constricted it, and gastrin and oxytocin caused no response, while the former constricted the artery and the latter three dilated it.
