The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Vitamin B6-Dependency of Glutamic Acid Decarboxylase in the Kidney from a Patient with Vitamin B6 Dependent Convulsion
TOSHIO YOSHIDA, KEIYA TADA, TSUNEO ARAKAWA
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Keywords: vitamin B6 dependent convulsion, glutamic acid decarboxylase (GAD), γ-aminobutyric acid (GABA)
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1971 Volume 104 Issue 2 Pages 195-198

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Abstract
In a patient with vitamin B6 dependent convulsions, the activity of glutamie acid decarboxylase (GAD) was found to be decreased when pyridoxal-phosphate (PALP) was not added in the reaction system for the enzyme assay. The activity was restored to normal level when PALP was added in large amounts in the reaction system. These findings suggest that the metabolic abnormality in this disorder exists in the binding abnormality between GAD apoenzyme and PALP.
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