The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Vitamin B6-Dependency of Glutamic Acid Decarboxylase in the Kidney from a Patient with Vitamin B6 Dependent Convulsion
TOSHIO YOSHIDA, KEIYA TADA, TSUNEO ARAKAWA
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キーワード: vitamin B6 dependent convulsion, glutamic acid decarboxylase (GAD), γ-aminobutyric acid (GABA)
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1971 年 104 巻 2 号 p. 195-198

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In a patient with vitamin B6 dependent convulsions, the activity of glutamie acid decarboxylase (GAD) was found to be decreased when pyridoxal-phosphate (PALP) was not added in the reaction system for the enzyme assay. The activity was restored to normal level when PALP was added in large amounts in the reaction system. These findings suggest that the metabolic abnormality in this disorder exists in the binding abnormality between GAD apoenzyme and PALP.

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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.


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