The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Metabolism of Phosphatidylcholine in Brain and Liver of Developing Rats
NOBUKAZU CHIDA, TSUNEO ARAKAWA
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キーワード: phosphatidylcholine synthesis, brain, myelination
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1971 年 104 巻 4 号 p. 359-371

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Incorporation of CDP-choline-1, 2-14C into phosphatidylcholine by brain homogenate and microsome was found to be higher than that of liver before and during active myelination period in rats. Incorporation of S-adenosylmethionine-methyl-14C into phosphatidylcholine by brain microsome was about 1/20 of that by liver microsome in two-week-old rats. These results indicate that in developing rat brain, phosphatidylcholine may be synthesized by transmethylation, to some extent, in addition to the major pathway via CDP-choline.
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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.


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