Histometrical Studies of the Pulmonary Artery in Sudden Death of Young and Apparently Healthy Subjects

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A histometrical method to estimate the medial strength of the pulmonary artery was applied to the cases of sudden death in young and apparently healthy subjects and disclosed medial hypertrophy. Latent pulmonary hypertension was assumed in these cases from the histometrical results, and the development of shock was attributed to acute reduction of blood flow into the left ventricle of the heart. The cases were associated with adrenocortical atrophy and usually with excessive growth of lymphoid tissues and persistent thymus. Possible relations of adrenocortical atrophy and pulmonary hypertension was discussed.