The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Mumps Virus Neutralizing Antibody in Saliva Following Natural Infection
YASUO CHIBA, TOORU NAKAO
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キーワード: salivary IgA, neutralizing antibody, mumps
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1972 年 106 巻 1 号 p. 75-81

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Fifteen out of twenty patients with natural mumps have developed a rise of mumps virus neutralizing antibody in saliva. Except several cases, the time when the salivary neutralizing antibody titer reached the maximum, almost coincided with convalescence of parotitis. The main class of immunoglobulin showing neutralizing activity was IgA. It is suggested that this IgA antibody is produced in salivary glands, and have an important role in suppression of mumps virus proliferation in salivary glands and in preventing the excretion of the virus into saliva.

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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.


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