抄録
Effect of periarterial nerve stimulation on the contraction, idioventricular rate and blood flow of the canine ventricular myocardium was investigated using the cross-circulated papillary muscle preparation with a constant perfusion pressure at 100mm Hg. Electrical stimulation of the periarterial nerve of the anterior septal artery (6-12 volts, 1-2 msee pulse-duration at 1-30 Hz) produced a pronounced increase of the isometric tension and idioventricular rate of the muscle with a little increase of the blood flow depending on the frequency of nerve stimulation. These effects of nerve stimulation were completely blocked by 0.3-1μg of tetrodotoxin which affected little the responses to norepinephrine (0.03μg) administered closearterially. These results show physiologically that sympathetic nerve innervates the ventricle through periarterial parts of the coronary artery and directly regulates the contraction, idioventricular automaticity and coronary flow of the canine ventricle.
